The dosage is based on your medical condition and response to treatment. Danazol can cause insulin resistance. Caution should be exercised when used with antidiabetic drugs. Androgen like effects include weight gain, acne and seborrhea. Mild hirsutism, edema, hair loss, voice change, which may take the form of hoarseness, sore throat or of instability or deepening of pitch, may occur and may persist after cessation of therapy. Hypertrophy of the clitoris is rare. Your pharmacist can provide more information about sirolimus.
The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.
Ask your health care provider any questions you may have about how to use danazol. Wentz AC "Adverse effects of danazol in pregnancy. You should not use this medication if you are allergic to sirolimus. If you have any questions about danazol, please talk with your doctor, pharmacist, or other health care provider.
Xiol X, Martinez-Lacasa J, Pons M, Marti E, Casais L "Jaundice after danazol therapy for endometriosis. FDA pregnancy category C. It is not known whether sirolimus will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. What should I avoid while taking danazol Danocrine?
Store sirolimus tablets at room temperature, away from heat, moisture, and light. Avoid getting sirolimus liquid on your skin or around your nose. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water. You may take sirolimus with or without food, but take it the same way every time. Keep out of the reach of children. Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose. Grapefruit and grapefruit juice may interact with sirolimus and could lead to potentially dangerous effects. Do not mix this medicine with grapefruit juice. Avoid eating grapefruit or drinking grapefruit juice while you are taking sirolimus. In the treatment of endometriosis, Danazol alters the normal and ectopic endometrial tissue so that it becomes inactive and atrophic. Complete resolution of endometrial lesions occurs in the majority of cases.
Danazol Capsules USP are indicated for the prevention of attacks of angioedema of all types cutaneous, abdominal, laryngeal in males and females. Thromboembolism, thrombotic and thrombophlebitic events including sagittal sinus thrombosis and life-threatening or fatal strokes have been reported. Using this medicine while you are pregnant can harm your unborn baby. If you are a woman who can bear children, your doctor may give you a pregnancy test before you start using this medicine to make sure you are not pregnant. Your birth control pills may not work as well while you are using this medicine. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. At first, 200 to 400 milligrams mg divided in two doses, for at least 3 to 6 months and up to 9 months. Your doctor may adjust your dose as needed and tolerated. FDA pregnancy category X. This medication can harm an unborn baby or cause vaginal birth defects in a newborn female infant. Do not use danazol if you are pregnant. Stop taking danazol and tell your doctor right away if you become pregnant during treatment. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. What happens if I miss a dose Danocrine? Danazol therapy. These alterations may be marked, and prescribers should consider the potential impact on the risk of atherosclerosis and coronary artery disease in accordance with the potential benefit of the therapy to the patient. Danazol of 400 mg or more. It is recommended that patients receiving Danazol be monitored for hepatic dysfunction by laboratory tests and clinical observation. Some MEDICINES MAY INTERACT with danazol. Lipitor, Caduet fluvastatin Lescol lovastatin Mevacor, Altoprev, Advicor pitavastatin Livalo pravastatin Pravachol rosuvastatin Crestor or simvastatin Zocor, Simcor, Vytorin, Juvisync. Sirolimus can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. Your blood may need to be tested often. Visit your doctor regularly. Ask your healthcare professional how you should dispose of any medicine you do not use. antabuse
Capsules of 200 mg orange bottles of 100 NDC 0024-0305-06. Benzyl alcohol as preservative. Before initiating therapy of fibrocystic breast disease with Danazol, carcinoma of the breast should be excluded. However, nodularity, pain, tenderness due to fibrocystic breast disease may prevent recognition of underlying carcinoma before treatment is begun. Therefore, if any nodule persists or enlarges during treatment, carcinoma should be considered and ruled out. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. Although cyclical bleeding and ovulation usually return within 60 to 90 days after discontinuation of therapy with Danazol, persistent amenorrhea has occasionally been reported. Endocrine side effects have included the inhibition of estrogen synthesis, resulting in flushing, sweating, vaginal dryness and irritation, and reduction in breast size. During administration of danazol the active ingredient contained in Danocrine endogenous testosterone synthesis and release may be inhibited through feedback inhibition of pituitary luteinizing hormone LH. Large doses of danazol may suppress spermatogenesis through inhibition of pituitary follicle stimulating hormone FSH. Danazol may decrease levels of thyroxine-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged and there is no clinical evidence of thyroid dysfunction. Quagliarello J, Greco MA "Danazol and urogenital sinus formation in pregnancy. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Inactive Ingredients: Corn Starch, Lactose, Magnesium Stearate, Talc. What are the possible side effects of danazol Danocrine? Sirolimus is used to prevent your body from rejecting a transplanted kidney. Sirolimus is sometimes used in a combination treatment with cyclosporine Neoral, Sandimmune and a steroid medicine such as prednisone. Overdose symptoms may include some of the serious side effects listed in this medication guide. This product's label may have been updated. If you miss a dose of danazol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once. The opinions expressed in WebMD User-generated content areas like communities, reviews, ratings, or blogs are solely those of the User, who may or may not have medical or scientific training. These opinions do not represent the opinions of WebMD. User-generated content areas are not reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other reason except for compliance with our Terms and Conditions. etok.info hydroxyzine
Changes in vaginal cytology and cervical mucus reflect the suppressive effect of Danazol on the pituitary-ovarian axis. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Women who may become pregnant must have a negative pregnancy test before beginning treatment with danazol. Miller EJ, Coleman FH "Pseudohypertestosteronemia during danazol therapy. A case report. Undiagnosed abnormal genital bleeding. How should I take danazol Danocrine? It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects. Avoid getting this medication on your skin, or around your nose and mouth. If it does get onto any of these areas, wash with soap and water. If this medicine gets into your eyes, rinse them with plain water. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Mercaitis PA, Peaper RE, Schwartz PA "Effect of danazol on vocal pitch: a case study. Your doctor may occasionally change your dose to make sure you get the best results. The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. It may take several weeks before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve or if they get worse during treatment. Webb AM, Russell J, Elstein M "Comparison of Yuzpe regimen, danazol, and mifepristone RU486 in oral postcoital contraception. Nakajima T, Mizushima N, Matsuda H, Matsumoto M, Tamakoshi K, Ishii H, Morioka S, Ikeda Y, Terao T, Kanai K "Fulminant hepatic failure associated with aplastic anaemia after treatment with danazol. Case report.
To assure that the patient is not pregnant, therapy should be initiated during menstruation. If this is not possible, a sensitive pregnancy test that detects early pregnancy should be done to insure the patient is not pregnant. A non- hormonal birth control method is recommended. Store danazol at room temperature, between 59 and 86 degrees F 15 and 30 degrees C in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep danazol out of the reach of children and away from pets. Experience with long-term therapy with danazol is limited. Peliosis hepatis and benign hepatic adenoma have been observed with long-term use. Peliosis hepatis and hepatic adenoma may be silent until complicated by acute, potentially life-threatening intraabdominal hemorrhage. The physician therefore should be alert to this possibility. Attempts should be made to determine the lowest dose that will provide adequate protection. If the drug was begun at a time of exacerbation of hereditary angioneurotic edema due to trauma, stress or other cause, periodic attempts to decrease or withdraw therapy should be considered. Your pharmacist can provide more information about danazol. Stop using this medicine and check with your doctor if you have the following symptoms while taking this medicine: blurred vision; change in the ability to see colors, especially blue or yellow; headache; nausea; or vomiting. Tell your doctor all medications and supplements you use. Therapy should begin during menstruation. What other drugs will affect sirolimus Rapamune? Do not use any other liquids to mix this medicine. Store at room temperature away from light and moisture. not store in the bathroom. Keep all away from children and pets. Hematologic side effects have included thromboembolic and thrombophlebotic events including sagittal sinus thrombosis some resulting in fatal strokes, and increased red cell production. Danazol may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking danazol. discount mectizan capsules
Use this medication regularly to get the most benefit from it. To help you remember, take it at the same times each day. Absorption: After oral administration of a 400 mg dose to healthy male volunteers, peak plasma concentrations of Danazol are reached between 2 and 8 hours, with a median T max value of 4 hours. Steady state conditions are observed following 6 days of twice daily dosing of Danazol. Acne; changes in menstrual flow eg, spotting; changes in semen volume; decrease in breast size; excessively oily skin; flushing; hair loss; mild weight gain; sweating; vaginal itching or dryness; voice changes hoarseness, sore throat, change in pitch. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Drugs. Side Effects List Danocrine Capsule side effects by likelihood and severity. Danazol can increase the calcemic response to synthetic vitamin D analogs in primary hypoparathyroidism. Brunskill PJ "The effects of fetal exposure to danazol. Use and dose must be determined by your doctor. Food and Drug Administration. WebMD does not endorse any specific product, service, or treatment. Other possible endocrine effects are menstrual disturbances including spotting, alteration of the timing of the cycle and amenorrhea. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns irregular menstrual patterns and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danocrine. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated. This medicine should not be given to a child younger than 13 years old. The following reactions have been reported, a causal relationship to the administration of Danocrine has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. generic mestinon uk next day
Danazol appears to be metabolized and the metabolites are eliminated by renal and fecal pathways. The two primary metabolites excreted in the urine are 2-hydroxymethyl Danazol and ethisterone. At least ten different products were identified in feces. All medicines may cause side effects, but many people have no, or minor, side effects. These hormones usually make the conditions worse. Seifer DB, Freedman LN, Cavender JR, Baker RA "Insulin-dependent diabetes mellitus associated with danazol. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication not have serious side effects. Do NOT take more medicine than prescribed unless advised to do so by your doctor.
Shaw RW, Farquhar JW "Female pseudohermaphroditism associated with danazol exposure in utero. Case report. Capsules of 100 mg yellow bottles of 100 NDC 0024-0304-06. What should I discuss with my healthcare provider before taking danazol? Baker HW, Snedecor PA "Clinical trial of danazol for benign breast disease. This list is not complete and other drugs may interact with danazol. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Stir the mixture and drink all of it right away. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive. Jick SS, Myers MW "A study of danazol's safety. Peress MR, Kreutner AK, Mathur RS, Williamson HO "Female pseudohermaphroditism with somatic chromosomal anomaly in association with in utero exposure to danazol. Tell your doctor if you become pregnant during treatment. Use effective birth control while you are using this medication and for at least 12 weeks after your treatment ends. In most instances, breast pain and tenderness are significantly relieved by the first month and eliminated in 2 to 3 months. Usually elimination of nodularity requires 4 to 6 months of uninterrupted therapy. Regular menstrual patterns, irregular menstrual patterns, and amenorrhea each occur in approximately one-third of patients treated with 100 mg of Danazol capsules. Irregular menstrual patterns and amenorrhea are observed more frequently with higher doses. Clinical studies have demonstrated that 50% of patients may show evidence of recurrence of symptoms within one year. In this event, treatment may be reinstated. Taking danazol to treat endometriosis may increase your risk of ovarian cancer. Talk with your doctor about your individual risk. buy labetalol strips
Capsules of 50 mg orange and white bottles of 100 NDC 0024-0303-06. Moderate. These medicines may cause some risk when taken together. LOT of weight, my voice lowered, and I grew hair like crazy on my face. It's nearly 25 years later, and I still have a low voice, dark thick hair that grows all over my face, and I'm still struggling with my weight. I'm also convinced this medication had an effect on my ears, as I've had problems with vertigo since taking Danocrine. If you are taking Rapamune oral liquid with a disposable syringe, you may store a loaded syringe in the carrying case provided. Keep the case at room temperature and use the medicine within 24 hours. Use a disposable syringe only once and then throw it away. Fermand JP, Levy Y, Bouscary D, D'Agay MF, Clot P, Frija J, Brouet JC "Danazol-induced hepatocellular adenoma. If this occurs, the drug should be discontinued. Do not start, stop, or change the dosage of any medicine before checking with them first. mail order cheapest indocin otc
Lab tests, including liver function tests and complete blood cell counts, may be performed while you use danazol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Danazol has been associated with several cases of benign intracranial hypertension also known as pseudotumor cerebri. Early signs and symptoms of benign intracranial hypertension include papilledema, headache, nausea and vomiting, and visual disturbances. Patients with these symptoms should be screened for papilledema and, if present, the patients should be advised to discontinue danazol immediately and be referred to a neurologist for further diagnosis and care. Yaginuma T, Okamura T, Takeuchi T, Nishii O, Fujimori R "Preventive effect of traditional herbal medicine, shosaiko-to, on danazol-induced hepatic damage. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist. Sirolimus lowers your body's immune system. The immune system helps your body fight infections. The immune system can also fight or "reject" a transplanted organ such as a liver or kidney. This is because the immune system treats the new organ as an invader. Tell your doctor or dentist that you take danazol before you receive any medical or dental care, emergency care, or surgery. Martino S "Danazol induced hypercalcemia in breast cancer. Breastfeeding. 5. Porphyria - Danazol can induce ALA synthetase activity and hence porphyrin metabolism. 6. Androgen-dependent tumor. 7. Active thrombosis or thromboembolic disease and history of such events. 8. Hypersensitivity to Danazol. In the treatment of hereditary angioedema, Danazol at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal. In addition, Danazol corrects partially or completely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor C1EI. As a result of this action the serum levels of the C4 component of the complement system are also increased. Danazol may raise the plasma levels of cyclosporin and tacrolimus, leading to an increase of the renal toxicity of these drugs. Monitoring of systemic concentrations of these drugs and appropriate dose adjustments may be needed when used concomitantly with Danazol. Check with your doctor right away if you are a female and have a larger clitoris sexual organ deepening of your voice, or unusual hair growth after taking danazol. Your doctor may advise you to stop taking the medicine so these side effects do not get worse.
Do not use Danocrine if you are pregnant. Tell your doctor if you become pregnant during treatment. Before you start taking Danocrine, you may need to have a to make sure you are not pregnant. Use an effective barrier form of birth control such as a condom or with spermicide gel or inserts. Hormonal contraception such as birth control pills, injections, implants, skin patches, and vaginal rings may not be effective to prevent pregnancy during treatment. Breastfeeding is not recommended while using this drug. These conditions can be made worse by the fluid retention keeping too much body water that can be caused by this medicine. In moderate to severe disease, or in patients infertile due to endometriosis, a starting dose of 800 mg given in two divided doses is recommended. Amenorrhea and rapid response to painful symptoms is best achieved at this dosage level. Gradual downward titration to a dose sufficient to maintain amenorrhea may be considered depending upon patient response. For mild cases, an initial daily dose of 200 mg to 400 mg given in two divided doses is recommended and may be adjusted depending on patient response. Therapy should begin during menstruation. Otherwise, appropriate tests should be performed to ensure that the patient is not pregnant while on therapy with Danocrine. MACE in association with use of testosterone replacement therapy in men. Tell your doctor if your condition does not improve or if it worsens. Follow your doctor's instructions about any restrictions on food, beverages, or activity. Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; abnormal hair growth; burning, numbness, or tingling; calf or leg pain, redness, tenderness, or swelling; chest pain; dizziness; fainting; fast or irregular heartbeat; fever, chills, or persistent sore throat; headache; mental or mood changes eg mood swings, nervousness; nausea; red, swollen, blistered, or peeling skin; seizures; shortness of breath; sudden, unexplained weight gain; swelling of the hands, ankles, legs, or feet; symptoms of liver problems eg, yellowing of the skin or eyes, dark urine, pale stools, stomach pain, loss of appetite, unusual tiredness; symptoms of stroke eg, one-sided weakness, slurred speech, confusion; unusual bleeding or bruising; vision problems; vomiting. Danocrine is indicated for the treatment of endometriosis amenable to hormonal management. Sirolimus can lower the blood cells that help your body fight infections. Avoid contact with people who have colds, the flu, or other contagious illnesses. Do not receive any vaccines without your doctor's advice. Contact your doctor immediately if you develop signs of infection. Danazol may rarely cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness, or other discoloration of the skin, or a severe sunburn. Check with your doctor if this occurs. If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip themissed dose and resume your usual dosing schedule. Store at room temperature away from moisture and heat. Active thrombosis or thromboembolic disease and history of such events. tizanidine
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Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. In the treatment of hereditary angioedema, Danocrine at effective doses prevents attacks of the disease characterized by episodic edema of the abdominal viscera, extremities, face, and airway which may be disabling and, if the airway is involved, fatal. In addition, Danocrine corrects partially or completely the primary biochemical abnormality of hereditary angioedema by increasing the levels of the deficient C1 esterase inhibitor C1EI. As a result of this action the serum levels of the C4 component of the complement system are also increased.
See PRECAUTIONS: Pregnancy, Teratogenic Effects. Store at room temperature away from moisture and heat. What happens if I miss a dose? Women who take danazol to treat endometriosis or fibrocystic breast disease should start the medication during a menstrual period. If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. What happens if I overdose Rapamune?
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. In this event, treatment may be reinstated. Generally, the pituitary-suppressive action of Danocrine is reversible. Ovulation and cyclic bleeding usually return within 60 to 90 days when therapy with Danocrine is discontinued. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. If your symptoms do not improve or if they become worse, check with your doctor.
The presence of other medical problems may affect the use of this medicine. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. The following reactions have been reported, a causal relationship to the administration of Danazol has neither been confirmed nor refuted; allergic: urticaria, pruritus and rarely, nasal congestion; CNS effects: headache, nervousness and emotional lability, dizziness and fainting, depression, fatigue, sleep disorders, tremor, paresthesias, weakness, visual disturbances, and rarely, benign intracranial hypertension, anxiety, changes in appetite, chills, and rarely convulsions, Guillain-Barre syndrome; gastrointestinal: gastroenteritis, nausea, vomiting, constipation, and rarely, pancreatitis and splenic peliosis; musculoskeletal: muscle cramps or spasms, or pains, joint pain, joint lockup, joint swelling, pain in back, neck, or extremities, and rarely, carpal tunnel syndrome which may be secondary to fluid retention; genitourinary: hematuria, prolonged posttherapy amenorrhea; hematologic: an increase in red cell and platelet count. Reversible erythrocytosis, leukocytosis or polycythemia may be provoked. Eosinophilia, leukopenia and thrombocytopenia have also been noted. Skin: rashes maculopapular, vesicular, papular, purpuric, petechial and rarely, sun sensitivity, Stevens-Johnson syndrome and erythema multiforme; other: increased insulin requirements in diabetic patients, change in libido, myocardial infarction, palpitation, tachycardia, elevation in blood pressure, interstitial pneumonitis, and rarely, cataracts, bleeding gums, fever, pelvic pain, nipple discharge. Malignant liver tumors have been reported in rare instances, after long-term use.